* Ces horaires sont donnés à titre indicatif.
Course objectives: to provide an overview of advanced methods of modern synthetic chemistry, focusing here on
carbon-carbon bond forming carbonyl reactions, as well as of the current efforts at developing sustainable alternatives.
Starting with some of the classical reactions from the undergraduate program, we will provide modern variants,
asymmetric versions (with an overview of the major transition state models), “greener” methods, and examples in total
synthesis.
The Grignard reaction
• Advanced methods
• Asymmetric versions
• Sustainable methods
• Total synthesis
The Aldol reaction
• Advanced methods
• Asymmetric versions
• Sustainable methods
• Total synthesis
The Wittig reaction
• Advanced methods
• Asymmetric versions
• Sustainable methods
• Total synthesis
Conjugate addition reactions
• Advanced methods
• Asymmetric versions
• Sustainable methods
• Total synthesis
Alpha substitution reactions
• Advanced methods
• Asymmetric versions
• Sustainable methods
Acquired Skills: a working knowledge of modern synthetic methods in carbonyl chemistry, a knowledge of the major
transition state models used to predict the stereochemical outcome of asymmetric reactions, and the ability to read
and understand the reactions, selectivities and specificities, and retrosynthetic strategy of the total synthesis of a
complex natural product
Type | Libellé | Nature | Coef. | ||
---|---|---|---|---|---|
CT | Contrôle Terminal | CT : Methods carbonyl | Ecrit session 1 / Ecrit session 2 | 3 |