* Ces horaires sont donnés à titre indicatif.
Course objectives: to provide an overview of advanced methods of modern synthetic chemistry, focusing here on the
chemistry of C=C Π bonds, as well as of the current efforts at developing sustainable alternatives. Starting with some
of the classical reactions from the undergraduate program, we will provide modern variants, asymmetric versions (with
an overview of the major transition state models), “greener” methods, and examples in total synthesis.
The Diels Alder reaction
• Advanced methods
• Asymmetric versions (rel. diastereoselection, induction, “enantioselective” versions)
• Sustainable methods
• Total synthesis
[3+2] Dipolar Cycloaddition reactions
• Advanced methods
• Asymmetric versions
• Sustainable methods
• Total synthesis
The Suzuki reaction
• idem
The Olefin Metathesis reaction
• idem
Directed metallation reactions
• idem
Radical cyclisation reactions
• idem
Photochemical processes
• Photon as a green reagent
• Applications in natural product synthesis
Acquired Skills: a working knowledge of modern synthetic methods in the chemistry of C=C Π bonds, a knowledge of
the major transition state models used to predict the stereochemical outcome of asymmetric reactions, and the ability
to read and understand the reactions, selectivities and specificities, and retrosynthetic strategy of the total synthesis of
a complex natural product
Type | Libellé | Nature | Coef. | ||
---|---|---|---|---|---|
CT | Contrôle Terminal | CT : Methods fod C=C bonds | Ecrit session 1 / Ecrit session 2 | 3 |