* Ces horaires sont donnés à titre indicatif.
Course objectives: to provide an overview of advanced methods of modern synthetic chemistry, focusing here on
functional group conversions, as well as of the current efforts at developing sustainable alternatives. Starting with
some of the classical reactions from the undergraduate program, we will provide advanced methods, asymmetric
versions (with an overview of the major transition state models), ‘greener’ methods, and examples in total synthesis.
Carbonyl reduction reactions
• Advanced methods
• Asymmetric versions
• Sustainable methods
Alkene reductions
• Advanced methods
• Asymmetric versions
• Sustainable methods
Alcohol oxidation reactions
• Advanced methods
• Asymmetric versions
• Sustainable methods
The dihydroxylation reaction
• Idem
Epoxidation reactions
• Idem
Nucleophilic substitution reactions
• Idem
Elimination reactions
• Idem
Radical substitution reactions
• Idem
FG conversions in total synthesis
Acquired Skills: a working knowledge of modern synthetic methods in functional group chemistry, a knowledge of the
major transition state models used to predict the stereochemical outcome of asymmetric reactions, and the ability to
read and understand the reactions, selectivities and specificities, and retrosynthetic strategy of the total synthesis of a
complex natural product
Type | Libellé | Nature | Coef. | ||
---|---|---|---|---|---|
CT | Contrôle Terminal | CT : Methods funct. groups | Ecrit session 1 / Ecrit session 2 | 3 |