Université Lyon 1
Université de Lyon
Accueil  >>  Master  >>  Biologie moléculaire et cellulaire  >>  Leading international vaccinology education (ERASMUS+)  >>  Immunomonitoring of preclinical and clinical vaccine trials
  • Domaine : Masters du domaine SCIENCES, TECHNOLOGIES, SANTE
  • Diplôme : Master
  • Mention : Biologie moléculaire et cellulaire
  • Parcours : Leading international vaccinology education (ERASMUS+)
  • Unité d'enseignement : Immunomonitoring of preclinical and clinical vaccine trials
Nombre de crédits de l'UE : 3
Code APOGEE : BIO2494M
UE Obligatoire pour ce parcours
UE valable pour le semestre 3 de ce parcours
    Responsabilité de l'UE :
DELPRAT CHRISTINE
 christine.delpratuniv-lyon1.fr
04.72.68.19.54
    Type d'enseignement
Nb heures *
Cours Magistraux (CM)
10 h
Travaux Dirigés (TD)
0 h
Travaux Pratiques (TP)
30 h
Total du volume horaire
40 h

* Ces horaires sont donnés à titre indicatif.

    Conditions d'accès à l'UE :
Bachelor level in molecular and cellular biology, biochemistry, physiology, microbiology-virology and advanced level in immunology.
    Programme - Contenu de l'UE :
Université Jean Monnet Saint Etienne
Contact : Nicolas ROCHEREAU, Assistant-Professor
Phone : +33 4 77 42 14 67
e-mail : rochereau.nicolas@gmail.com

Keywords : animal models, immunomonitoring, preclinical, clinical

Aims of “Immuno-monitoring of preclinical and clinical vaccine trial”:
Practical work will teach the students how to monitor humoral and cellular immune response in mice, how to measure immune diversity. Practical immunology includes multi-parameter flow cytometry analysis, elispot assay, elisa, route of administration in mice, mouse immunology.

1. Methods of immunisation in mice, uptake of organs and secretions
2. Multiparameter flow cytometry
3. In vivo imaging
4. Monitoring of B cell responses (elispot, antibody titers)
5. Monitoring of T cells (cytometry, polyfunctionality, elispot)
6. Transcriptomic, Proteomic and Glyconomics tools of the measure of vaccine efficiency
7. New methods as the measure of immune diversity
8. Management of samples for vaccine trial (AQ)
9. Choice of the good animal model and correlate of protection or efficiency

Speakers:
Teaching Staff Immunology from University of Jean Monnet Saint-Etienne directed by J. Lisfranc.
Conferences concerning news items will be organized. Speakers will be invited based on their excellence.
Practical training for preclinical immunomonitoring will be done with the CEA in Fontenay aux Roses (2 days) and University of Jean Monnet Saint-Etienne.

Learning outcomes:
How to monitor vaccine efficiency in animal models and in humans.

Updated on April 9, 2019

    Compétences acquises :
Méthodologiques :
Learning outcomes:
How to monitor vaccine efficiency in animal models and in humans. 


Techniques :
Practical training for preclinical immunomonitoring will be done with the CEA in Fontenay aux Roses (2 days) and University of Jean Monnet Saint-Etienne.Multiparameter flow cytometry
Elispot, antibody titers
Transcriptomic, Proteomic and Glyconomics tools
    Modalités de contrôle des connaissances et Compétences 2020-2021:
TypeLibelléNatureCoef. 
CTContrôle TerminalCT : Immuno.preclini &clinic vacc trialsEcrit Session 1 / Oral Session 23
    Liste des autres Parcours / Spécialité / Filière / Option utilisant cette UE :
Date de la dernière mise-à-jour : 09/04/2019
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